Quipazine maleate is a 5-HT agonist that causes behavioral changes such as hyperactivity. It also shows a weak reversible MAO inhibitory activity. This piperazine-based nonselective serotonin receptor agonist targets several 5-HT receptor subtypes, including 5-HT₂A (pKi ≈ 6.9), 5-HT₂C (≈ 7.27), and 5-HT₂B, as well as showing marked agonist activity at 5-HT₃ (EC₅₀ ≈ 1.0 nM). It has been explored for anti-parkinsonian potential in preclinical settings and is a valuable pharmacological tool for studying serotonin receptor functions.
- 5-HT agonist
- Causes behavioral changes such as hyperactivity
- Weak reversible MAO inhibitory activity
- Nonselective serotonin receptor agonist
- Targets 5-HT₂A, 5-HT₂C, 5-HT₂B, and 5-HT₃ receptors
- Explored for anti-parkinsonian potential
- Valuable pharmacological tool for studying serotonin receptor functions